4-[(9H-fluoren-9-ylmethoxy)carbonyl]morpholine-3-carboxylic acid
4-[(9H-fluoren-9-ylmethoxy)carbonyl]morpholine-3-carboxylic acid
CAS: 204320-51-4
Molecular Formula: C20H19NO5
4-[(9H-fluoren-9-ylmethoxy)carbonyl]morpholine-3-carboxylic acid - Names and Identifiers
| Name | 4-[(9H-fluoren-9-ylmethoxy)carbonyl]morpholine-3-carboxylic acid |
| Synonyms | FMOC-COP FMOC-COP-OH RARECHEM EM WB 0088 (R,S)-FMOC-2-CARBOXYMORPHOLINE FMOC-(R,S)-2-CARBOXYMORPHOLINE 4-[(9H-fluoren-9-ylmethoxy)carbonyl]morpholine-3-carboxylic acid 4-[(9H-Fluoren-9-ylmethoxy)carbonyl]morpholine-2-carboxylic acid 4-[(9H-Fluoren-9-ylmethoxy)carbonyl]morpholine-3-carboxylic Acid |
| CAS | 204320-51-4 |
| InChI | InChI=1/C20H19NO5/c22-19(23)18-12-25-10-9-21(18)20(24)26-11-17-15-7-3-1-5-13(15)14-6-2-4-8-16(14)17/h1-8,17-18H,9-12H2,(H,22,23) |
4-[(9H-fluoren-9-ylmethoxy)carbonyl]morpholine-3-carboxylic acid - Physico-chemical Properties
| Molecular Formula | C20H19NO5 |
| Molar Mass | 353.37 |
| Density | 1.344±0.06 g/cm3(Predicted) |
| Boling Point | 579.8±50.0 °C(Predicted) |
| Flash Point | 304.4°C |
| Vapor Presure | 2.77E-14mmHg at 25°C |
| pKa | 3.47±0.20(Predicted) |
| Storage Condition | 2-8℃ |
| Refractive Index | 1.621 |
4-[(9H-fluoren-9-ylmethoxy)carbonyl]morpholine-3-carboxylic acid - Risk and Safety
| Hazard Symbols | N - Dangerous for the environment |
| Risk Codes | 50 - Very Toxic to aquatic organisms |
| Safety Description | 61 - Avoid release to the environment. Refer to special instructions / safety data sheets. |
| Hazard Class | IRRITANT |
4-[(9H-fluoren-9-ylmethoxy)carbonyl]morpholine-3-carboxylic acid - Introduction
4-[(9H-fluoren-9-ylmethoxy)carbonyl]morpholine-3-carboxylic acid is an organic compound, which has the following properties:
1. Appearance: 4-[(9H-fluoren-9-ylmethoxy)carbonyl]morpholine-3-carboxylic acid is a solid, usually white or light yellow crystalline.
2. Solubility: it has good solubility in common organic solvents, such as dimethyl sulfoxide (DMSO), dichloromethane and ethyl acetate.
4-[(9H-fluoren-9-ylmethoxy)carbonyl]morpholine-3-carboxylic acid is mainly used as a protecting group in organic synthesis. It is widely used as a protecting group for amino acids, polypeptides and proteins in drug synthesis and biochemistry. It can protect the amino (-NH2) functional group from accidental chemical reactions or immobilization during solid-phase synthesis.
Preparation of 4-[(9H-fluoren-9-ylmethoxy)carbonyl]morpholine-3-carboxylic acid is usually synthesized by the following steps:
1. Esterifying morpholine carboxylic acid and 4-fluoroacyl benzoic acid to generate 4-[(9H-fluoren-9-ylmethoxy)carbonyl]morpholine-3-carboxylic acid ester.
2. The reaction product is treated by hydrolysis reaction to generate 4-[(9H-fluoren-9-ylmethoxy)carbonyl]morpholine-3-carboxylic acid.
Note the following security information when using 4-[(9H-fluoren-9-ylmethoxy)carbonyl]morpholine-3-carboxylic acid:
1. 4-[(9H-fluoren-9-ylmethoxy)carbonyl]morpholine-3-carboxylic acid is a chemical substance. It should be operated in a well-ventilated environment to avoid inhalation or contact with skin and eyes.
2. Use appropriate personal protective equipment, such as protective glasses, laboratory gloves and respiratory protective equipment.
3. Avoid contact with oxidants, acids and other substances during storage and handling to prevent possible dangerous reactions.
4. Be sure to read and understand the relevant safety instructions and operating instructions carefully before use, and follow the correct operating procedures. In case of accident or discomfort, seek medical help immediately.
1. Appearance: 4-[(9H-fluoren-9-ylmethoxy)carbonyl]morpholine-3-carboxylic acid is a solid, usually white or light yellow crystalline.
2. Solubility: it has good solubility in common organic solvents, such as dimethyl sulfoxide (DMSO), dichloromethane and ethyl acetate.
4-[(9H-fluoren-9-ylmethoxy)carbonyl]morpholine-3-carboxylic acid is mainly used as a protecting group in organic synthesis. It is widely used as a protecting group for amino acids, polypeptides and proteins in drug synthesis and biochemistry. It can protect the amino (-NH2) functional group from accidental chemical reactions or immobilization during solid-phase synthesis.
Preparation of 4-[(9H-fluoren-9-ylmethoxy)carbonyl]morpholine-3-carboxylic acid is usually synthesized by the following steps:
1. Esterifying morpholine carboxylic acid and 4-fluoroacyl benzoic acid to generate 4-[(9H-fluoren-9-ylmethoxy)carbonyl]morpholine-3-carboxylic acid ester.
2. The reaction product is treated by hydrolysis reaction to generate 4-[(9H-fluoren-9-ylmethoxy)carbonyl]morpholine-3-carboxylic acid.
Note the following security information when using 4-[(9H-fluoren-9-ylmethoxy)carbonyl]morpholine-3-carboxylic acid:
1. 4-[(9H-fluoren-9-ylmethoxy)carbonyl]morpholine-3-carboxylic acid is a chemical substance. It should be operated in a well-ventilated environment to avoid inhalation or contact with skin and eyes.
2. Use appropriate personal protective equipment, such as protective glasses, laboratory gloves and respiratory protective equipment.
3. Avoid contact with oxidants, acids and other substances during storage and handling to prevent possible dangerous reactions.
4. Be sure to read and understand the relevant safety instructions and operating instructions carefully before use, and follow the correct operating procedures. In case of accident or discomfort, seek medical help immediately.
Last Update：2024-04-09 19:05:47
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